Beginning a Clinical Research Study
Bruce L. Pihlstrom DDS, MS
Learn about beginning a clinical research study by identifying a mentor and biostatistician, understanding the basic principles of defining and answering a research question, establishing a testable research hypothesis and choosing an appropriate research design.
1. Learn how to identify and work with a research mentor and a biostatistician
- Characteristics of a good research learner
- Characteristics of a good research mentor
- Establishing an ongoing relationship with a research mentor and statistician
2. Learn the importance and characteristics of a focused research question that forms the basis of a clinical research study.
3. Learn how the research question can be refined using specific steps:
- P for Problem/person/patient/population
- I for Intervention or exposure under consideration
- C for Comparison/Control intervention or exposure
- O for Outcomes
4. Learn how to state the research question as a hypothesis in terms of the independent and dependent variables that can be can be tested in a clinical research study.
- Null hypothesis
- Alternative hypothesis
5. Learn about choosing a research design that is appropriate for the question being asked.
- Observational study (retrospective/prospective)
- Clinical trial
“Beginning a Clinical Research Study” is co-sponsored by Tribune Group GmbH. Tribune Group GmbH is a recognized ADA CERP and AGD PACE provider.
At the end of the webinar, after passing the C.E. Quiz, you will be able to download your ADA CERP and AGD PACE C.E. Certificates.
Glossary – Definitions of Key Terms
- Alternative Hypothesis
- The alternative hypothesis, H1, is a statement of what a statistical hypothesis test is set up to establish. For example, in a clinical trial of a new drug, the alternative hypothesis might be that the new drug has a different effect, on average, compared to that of the current drug.
- Dependent Variable
- Independent Variable
- Null Hypothesis
- The null hypothesis, H0, represents a theory that has been put forward, either because it is believed to be true or because it is to be used as a basis for argument, but has not been proved. For example, in a clinical trial of a new drug, the null hypothesis might be that the new drug is no better, on average, than the current drug.