This podcast discusses the concept of “disease reciprocity” and proposes a mechanism that might link gingivitis and obesity, based on metabolomic analysis.

After completing this podcast, listeners should be able to:

• Comprehend the suggested reciprocal pathogenic relationship between gingivitis and obesity.

Numerous studies indicate that periodontal disease significantly increases the risk of primary ischemic stroke and subsequent cardiovascular events. This presentation provides an overview of these studies, along with a review of the different stroke types and subtypes.

After completing this podcast, listeners should be able to:

• Categorize stroke types and subtypes and describe several reported associations between periodontal disease and ischemic stroke.

Periodontal disease is a risk factor for various adverse pregnancy outcomes. This presentation addresses four specific adverse outcomes associated with maternal periodontitis and stresses the importance of promoting oral health and oral health prophylaxis during pregnancy.

After completing this podcast, listeners should be able to:

• Name several adverse pregnancy outcomes associated with periodontal disease and describe a potential mechanism linking periodontal infection to these outcomes.

Over the past 15+ years, a possible association between Alzheimer disease (AD) and periodontitis has emerged. This presentation describes the role that P. gingivalis might play in linking these two inflammatory and degenerative diseases. A promising new therapeutic option for both periodontal disease and AD, currently being evaluated in clinical trials, is also discussed.

After completing this podcast, listeners should be able to:

• Identify a potential mechanistic link between periodontitis and Alzheimer disease, as well as a new promising approach to treat both diseases.